The world of neuromodulators just got more exciting. Letybo, the newest FDA-approved injectable neurotoxin, received approval in February 2024 and is now available in the United States. As Glendale’s award-winning med spa with over 400 five-star Google reviews, Touch and Glow Med Spa is here to help you understand this new option and how it compares to the gold standard, Botox.

If you’re searching for Botox near me or neuromodulator treatments in Glendale, AZ, you might be wondering: Should I try Letybo or stick with Botox? This comprehensive guide will help you make an informed decision.

 

What is Letybo?

Letybo is an injectable formulated with letibotulinumtoxinA, a botulinum toxin type A that functions similarly to other neuromodulators like Botox, Dysport, Xeomin, Jeuveau, and Daxxify. While it’s new to the United States, Letybo has an impressive international track record.

Letybo has been the number one neuromodulator in South Korea for over a decade, with over 31 million successful treatments performed globally across 65 countries. It’s a trusted brand backed by extensive clinical research and years of real-world results.

 

How Letybo Works

Like Botox, Letybo works by blocking nerve signals in the injected muscles, which prevents the muscles from contracting. This temporary relaxation of facial muscles leads to a reduction in the appearance of wrinkles on the skin’s surface.

Currently, Letybo is FDA-approved to treat moderate-to-severe glabellar lines (frown lines between the eyebrows), with injections administered at five sites within the muscles.

 

What is Botox?

Botox (onabotulinumtoxinA) is the original and most well-known neuromodulator. Botox has accumulated FDA approvals for a wide range of cosmetic uses including forehead lines and crow’s feet, as well as numerous therapeutic applications such as chronic migraine, overactive bladder, and muscle spasticity.

With decades of clinical use and research, Botox has set the standard for wrinkle-reducing injectable treatments and remains the most recognized name in aesthetic medicine.

 

Letybo vs Botox: Key Similarities

Before diving into the differences, it’s important to understand that Letybo and Botox are remarkably similar:

Same Active Ingredient Type

Both Letybo and Botox contain purified forms of botulinum toxin type A—Botox’s technical name is onabotulinumtoxinA while Letybo is letibotulinumtoxinA.

Similar Mechanism of Action

Both work by temporarily blocking nerve signals to relax muscles that cause dynamic wrinkles.

Comparable Safety Profiles

Both products were FDA-approved following rigorous clinical trials assessing their safety and efficacy. Letybo’s FDA approval was based on evidence from three clinical trials involving 1,271 patients with moderate to severe frown lines.

Similar Treatment Experience

The injection process, number of injection sites, and overall patient experience are virtually identical between the two products.

Equivalent Efficacy

In clinical trials used to gain FDA approval, Letybo was found to deliver non-inferior results compared to Botox, meaning it worked just as well in reducing glabellar lines.

 

Letybo vs Botox: The Key Differences

While the two products are more similar than different, there are some distinctions worth noting:

Speed of Results

Letybo: Many patients report seeing results from Letybo in as little as 2 to 3 days. This faster onset is comparable to Dysport.

Botox: Botox typically takes 3 to 5 days to show initial results, with full effects visible at around two weeks.

Winner: Letybo has a slight edge for patients who want to see results faster, though the difference is minimal.

 

Duration of Results

Letybo: Clinical studies indicate that Letybo’s wrinkle-smoothing effects last approximately 3 to 4 months, with some reports suggesting it may last 12 to 16 weeks.

Botox: Results typically last 3 to 4 months as well.

Winner: Both products offer comparable longevity. Individual results vary based on metabolism, muscle strength, and treatment area.

 

FDA Approvals and Treatment Areas

Letybo: Currently FDA-approved specifically for treating moderate to severe glabellar lines (frown lines between the eyebrows). As a newer entrant to the market, Letybo gained approval for this single indication in 2024.

Botox: Botox has a long history of use in the United States and has accumulated FDA approvals for multiple cosmetic areas including forehead lines, crow’s feet, and frown lines, plus numerous therapeutic applications.

Winner: Botox currently has more FDA-approved treatment areas, though experienced injectors may use Letybo off-label for other facial areas.

 

Global Track Record

Letybo: Over a decade of use globally with over 31 million treatments across 65 countries, ranking as the number one neuromodulator in South Korea.

Botox: Decades of use in the United States and worldwide, with the longest track record and most extensive clinical data of any neuromodulator.

Winner: Botox has the longest U.S. history, but Letybo’s impressive international track record shouldn’t be overlooked.

 

Market Position and Pricing

Letybo: Letybo is only the sixth neuromodulator to receive FDA approval in over 20 years. As a newer option, it may offer competitive pricing as it establishes market presence.

Botox: Remains the market leader with the highest name recognition and most established pricing structure.

Winner: Pricing varies by provider and market conditions. Contact Touch and Glow Med Spa for current pricing on both products.

 

Clinical Trial Results: How Do They Compare?

Letybo Clinical Trials

In the three FDA approval trials, Letybo demonstrated significant improvement in frown lines. In Trial BLESS I, 47% of patients treated with Letybo showed improvement compared to 0% with placebo. In Trial BLESS II, 49% improved versus 2% with placebo. In Trial BLESS III, 65% showed improvement versus 0% with placebo.

 

What the Experts Say

According to Dr. Sue Ellen Cox, a board-certified dermatologist and investigator in Letybo’s clinical trials, “It’s going to work just as well as Botox, but we’re not going to see a big difference when it comes to patients being able to distinguish it from the other neuromodulators”.

Dr. Connie Yang, a board-certified dermatologist, notes that “all of these products are more similar than they are different”.

 

Who is a Good Candidate for Letybo vs Botox?

Consider Letybo If You:

• Want to try the newest FDA-approved neuromodulator
• Appreciate having a faster onset of results (2-3 days)
• Are interested in a product with an extensive international track record
• Have developed resistance to other neuromodulators and need an alternative
• Are seeking competitive pricing on a high-quality neuromodulator

Consider Botox If You:

• Prefer the most established neuromodulator with decades of U.S. clinical data
• Need treatment for multiple FDA-approved areas beyond frown lines
• Want a product with therapeutic applications for conditions like migraines
• Are comfortable with a 3-5 day onset time
• Prefer the most recognized brand name in aesthetic medicine

The Truth About “Botox Resistance”

Some patients develop resistance to certain neuromodulator formulas over time. This issue can usually be avoided by switching to a formula that uses a different accompanying protein or peptide. Patients may consider Letybo if another formula has yielded diminished results over time.

At Touch and Glow Med Spa, our experienced medical professionals can help you determine if switching to Letybo might benefit you.

 

Safety Considerations: Letybo and Botox

Both Letybo and Botox carry similar safety profiles and FDA warnings:

 

Common Side Effects

The most common adverse reaction for both products is headache. Other potential side effects include:

• Temporary redness at injection sites
• Mild swelling or bruising
• Temporary muscle weakness near injection sites

Important Safety Information

Both products carry a boxed warning about the potential distant spread of toxin effects, which can occur hours to weeks after injection and may include potentially life-threatening swallowing and breathing difficulties.

However, when administered by qualified, experienced medical professionals like the team at Touch and Glow Med Spa, both products have excellent safety records.

 

Who Should NOT Use Letybo or Botox

You should not receive neuromodulator treatments if you:

• Are allergic to botulinum toxin products
• Have an infection at the injection site
• Are pregnant or breastfeeding
• Have certain neuromuscular disorders

Always discuss your complete medical history with your provider during your consultation.

 

What to Expect: Treatment Process for Both Products

Whether you choose Letybo or Botox at Touch and Glow Med Spa, your experience will be similar:

 

Before Treatment

• Comprehensive consultation to discuss your goals and medical history
• Facial assessment to determine optimal injection sites
• Transparent pricing discussion with no pressure to purchase
• All questions answered by our experienced medical professionals

During Treatment

For glabellar lines, the total recommended dose is 20 units per treatment session divided into five equal intramuscular injections of 4 units each—two injections in each corrugator muscle and one injection in the procerus muscle.

The entire injection process typically takes 10-15 minutes, with minimal discomfort.

 

After Treatment

• Minimal to no downtime—return to normal activities immediately
• Detailed aftercare instructions provided
• Follow-up available if you have any concerns

Results Timeline

Letybo:

• Initial results: 2-3 days
• Full results: 7-14 days
• Duration: 3-4 months

Botox:

• Initial results: 3-5 days
• Full results: 10-14 days
• Duration: 3-4 months

Making the Right Choice: Expert Guidance at Touch and Glow

As a family-owned and operated med spa with over 400 five-star Google reviews and recognition as the Best Med Spa in Glendale, AZ, Touch and Glow offers both Letybo and Botox treatments with expert care.

Why Choose Touch and Glow for Neuromodulator Treatments

Experienced Medical Professionals: Our team brings over 10 years of combined medical field experience and specialized training in facial anatomy and injection techniques.

No Pressure, Just Honest Advice: We treat you like family and never upsell treatments you don’t need. We’ll help you choose the best option for your specific needs and goals.

Award-Winning Service: Recognized as the Best Med Spa in Glendale, AZ, with over 400 five-star reviews on Google.

Transparent Pricing: All pricing available on our website—no surprises, no hidden fees.

Comprehensive Care: Whether you’re interested in Letybo, Botox, or other neuromodulators like Dysport or Xeomin, we offer multiple options to find your perfect match.

Natural-Looking Results: Our conservative, artistic approach ensures you look refreshed and rejuvenated—never frozen or overdone.

 

Beyond Neuromodulators: Comprehensive Aesthetic Solutions

At Touch and Glow Med Spa, we don’t just offer Letybo and Botox. We provide a full range of aesthetic services to address all your skincare and cosmetic needs:

• Dermal Fillers (including Radiesse)
• PDO Thread Lifts
• Microneedling (SkinPen and Vivace RF)
• Emsculpt Body Sculpting
• Microblading & Ombré Brows
• Lash Lift & Tint
• Professional Spray Tans

We truly are your one-stop-shop for all aesthetic treatments!

 

Frequently Asked Questions

Q: Is Letybo better than Botox?
A: Neither is objectively “better.” Letybo showed comparable results to Botox in FDA trials. The best choice depends on your individual needs, preferences, and how your body responds to treatment. Our team can help you decide.

Q: Can I switch from Botox to Letybo?
A: Yes! Many patients switch between neuromodulators. Treatments are typically spaced several months apart—usually every 3 to 4 months—after the previous neuromodulator’s effects have worn off.

Q: Will Letybo look different than Botox?
A: Most patients find that they cannot distinguish results between different neuromodulators when properly administered by an experienced injector.

Q: Is Letybo safe?
A: Yes. Letybo’s FDA approval was based on rigorous clinical trials involving over 1,271 patients, plus over 31 million successful treatments performed globally.

Q: How much does Letybo cost compared to Botox?
A: Pricing varies by provider and market conditions. Contact Touch and Glow Med Spa for current pricing on both products. We offer transparent pricing with no hidden fees.

Q: Can Letybo be used for areas other than frown lines?
A: While Letybo is currently FDA-approved only for moderate to severe glabellar lines, experienced injectors may feel comfortable using it off-label to treat other areas of the face, though patients should discuss risks and benefits with their provider.

Q: Which neuromodulator works fastest?
A: Letybo and Dysport both typically show results in 2-3 days, which is slightly faster than Botox’s 3-5 day onset.

 

The Bottom Line: Letybo and Botox at Touch and Glow

All doctors agree that adding another neuromodulator into the mix is ultimately a good thing for both providers and patients alike. More options mean better ability to customize treatments to individual needs and preferences.

Whether you choose Letybo or Botox, the most important factor is working with experienced, qualified medical professionals who understand facial anatomy, proper dosing techniques, and how to achieve natural-looking results.

At Touch and Glow Med Spa, we’re excited to offer Letybo as an additional option alongside our established neuromodulator treatments. Our team stays current with the latest aesthetic innovations while maintaining our commitment to safe, effective, personalized care.

 

Ready to Experience Expert Neuromodulator Treatment in Glendale?

If you’ve been searching for Botox near me or the best neuromodulator treatments in Glendale, AZ, Touch and Glow Med Spa is here to help you achieve your aesthetic goals with expert care and honest guidance.

 

Book Your Consultation Today

During your complimentary consultation, we’ll:

• Discuss your aesthetic goals and concerns
• Evaluate which neuromodulator is best for your needs (Letybo, Botox, or alternatives)
• Create a personalized treatment plan
• Provide transparent pricing with no hidden fees
• Answer all your questions thoroughly
• Never pressure you into treatments you don’t need

Take the next step toward smoother, more youthful-looking skin. Visit touchandglowskincare.com to book your appointment online, browse our full range of services, view pricing, and learn more about our family-owned med spa.

Join the hundreds of satisfied patients who trust Touch and Glow Med Spa for expert neuromodulator treatments in Glendale, Arizona. Experience the difference of working with a family that truly cares about your results and satisfaction.

Touch and Glow Med Spa
Where You Love to Glow

Family-Owned & Operated | Glendale, Arizona | 400+ Five-Star Google Reviews | Awarded Best Med Spa in Glendale, AZ

Serving Glendale, Phoenix, Peoria, Surprise, and surrounding Arizona areas

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Individual results may vary. Always consult with a qualified healthcare provider before undergoing any aesthetic treatment. Both Letybo and Botox carry risks and potential side effects. Discuss your complete medical history with your provider during consultation.